FourDerm Cream rarely shows side effects such as redness, rash, or itching at the site of application. These side effects are usually mild and resolve with time. However, consult your doctor if any of these side effects persist or worsen. FourDerm Cream is meant for external use only. Wash and dry the affected area. Apply a thin layer of this medicine to the affected area and spread uniformly. Do not cover the area with bandages or use heating pads unless directed by your doctor to do so. Keep the area away from water for at least one hour to prevent the medicine from getting rinsed. Avoid using it on broken skin or open wounds. Rinse immediately with water if this medicine comes in contact with the eyes, nose, mouth, and other sensitive parts, as it may cause irritation. FourDerm Cream is not recommended for use if you are allergic to it. Inform your doctor if you are using any other topical medicines.